To lock my throttle, I grab the throttle with my left hand, then twist the Throttlemeister. You can't twist both the throttle and the lock at the same time, it takes about a 50% throttle turn to lock the device.
I was riding to/from Sturgis in a big group, so I was having to tweak my throttle position once in a while. It wasn't a big deal.
My review, after my huge road trip was that the Throttlemeister is pretty nice! I wouldn't jump on it if you don't do any highway cruising. It's not very useful for anything but that.
If basic heavier weights are what you're after, get the Manic Salamander weights without the throttle lock.
If you want heavier weights and a throttle lock, nothing beats a Throttlemeister.
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